While multiple studies by Giovanni Damiani have demonstrated that bioinhibitor combination therapy may improve the relapse of psoriasis, there are specific issues of drug resistance and loss of response. 12–14 However, Johnson-Huang and colleagues 15 showed that many patients with moderate to severe psoriasis exhibit relapse after stopping treatment with biological agents. 11 Several clinical studies have shown that biological agents (eg, ustekinumab, secukinumab, ixekizumab, brodalumab, guselkumab, and tildrakizumab) can effectively alleviate the clinical symptoms of patients with moderate to severe psoriasis, reducing both the psoriasis area and severity index (PASI) score and incidence of side effects in patients with psoriasis. 10 In recent years, biological agents have become important treatments for patients with moderate to severe psoriasis. 9 Importantly, Cheng and colleagues showed that patients with psoriasis had a higher hospital readmission rate due to psoriasis and that readmission rates were increasing, resulting in a heavy economic burden. The occurrence, development, and recurrence of psoriasis are caused by multiple factors, including mechanical stress, drugs, infection, lifestyle, obesity, diabetes mellitus, dyslipidemia, hypertension, and mental stress. 5, 6 Studies by Icen 7 and Tollefson 8 showed that the incidence of psoriasis in children and adults is generally increasing. A global systematic review showed that the incidence of psoriasis in adults ranged from 0.51% to 11.43%, whereas that in children ranged from 0% to 1.37% the highest incidence rates of psoriasis were between 30 to 39 years old and between 50 to 69 years old. 4 Psoriasis can occur in both adults and children however, the prevalence varies among populations, regions, and ages.
Cytoscape networks skin#
2, 3 Moreover, the skin flora has been shown to differ between patients with psoriasis and healthy individuals. 1, 52 In this complex immune-mediated skin disease, T lymphocytes, keratinocytes, dendritic cells, and cytokines (eg, interleukin -23, IL-17, and tumor necrosis factor) play central roles in the pathophysiological mechanism of psoriasis. Psoriasis is a chronic, recurrent, inflammation- and immune-mediated skin disease that usually presents with varying degrees of skin itching and sharply demarcated erythematous plaques with whitish scales. Keywords: psoriasis, recurrence, cell cycle, gene expression profiling, pathogenic mechanism Functional enrichment analysis revealed that the cell cycle and oocyte meiosis signaling pathways were involved in the recurrence of psoriasis.Ĭonclusion: Our findings provided insights into the mechanisms mediating the onset and recurrence of psoriasis. Results: We screened out six core targets that played important roles in recurrence of psoriasis, and validation of GEO datasets and clinical samples showed that the expression levels of five core targets were higher in patients with psoriasis than in healthy individuals. Functional enrichment analysis was used to explore the potential mechanisms mediating the recurrence of psoriasis. The results were then validated by analysis of core targets using Gene Expression Omnibus (GEO) datasets and clinical samples. Methods: We analyzed differentially expressed genes to determine which targets were associated with the recurrence of psoriasis and used these data to construct a protein-protein interaction network using Cytoscape software. Accordingly, in this study, we aimed to identify markers associated with the recurrence of psoriasis. However, the genetic markers associated with recurrence have not yet been fully elucidated. An-Hai Li, 1 Wen-Wen Li, 2 Xiao-Qian Yu, 3 Dai-Ming Zhang, 4 Yi-Ran Liu, 5 Ding Li 1ġDepartment of Dermatology, Qingdao Huangdao District Central Hospital, Qingdao, People’s Republic of China 2Department of Hematology, Qingdao Women and Children’s Hospital, Qingdao, People’s Republic of China 3Department of Dermatology, Qingdao Haici Hospital (Qingdao Traditional Chinese Medicine Hospital), Qingdao, People’s Republic of China 4Department of Pharmacy, Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China 5College of Traditional Chinese Medicine, Weifang Medical College, Weifang, People’s Republic of ChinaĬorrespondence: Ding Li, Department of Dermatology, Qingdao Huangdao District Central Hospital, Qingdao, People’s Republic of China, Email īackground: Psoriasis is a recurrent, chronic, inflammation- and immune-mediated skin disease with multiple causative factors.
0 kommentar(er)
